Quantum Design Italy and DENSsolutions announce new partnership

Quantum Design Italy and DENSsolutions announce new partnership

DENSsolutions is proud to partner with Quantum Design Italy  to serve the Italian market. Quantum Design has been one of the leading European distributors of high-tech instrumentation for scientific, academic and industrial research for over 45 years. DENSsolutions will strengthen their TEM portfolio with innovative MEMS based In Situ solutions and together we can build and strengthen relationships with research groups in Italy.

“Since the first discussion with Ben, this felt like a perfect match! As a manufacturer of high-end scientific instruments and a distributor with a global network, Quantum Design is always looking for partnerships with companies that share the same passion for science and innovation. In the team of DENSsolutions we found people with the very same drive as us to bring the highest quality equipment into any lab. Both teams aim to provide scientists with tools to make their research possible, turn their ideas into results and work in close collaboration with them. That’s what both teams do, every single day. Together, we can be even closer to researchers, we love to think that this partnership will benefit mainly our customers (but we ourselves will also have a lot fun!).”

Diego Vitaglione, Managing Director – QD Italy

“Signing a distribution agreement with Quantum Design Italy S.r.l for DENSsolutions was a very special occasion for me. I am sure that working with the team in QD Italy will be a big pleasure for our team in Delft as everyone I met was very knowledgeable, energetic and passionate about their business; at DENSsolutions we like people who are passionate about Science and Business. As an added bonus, we signed this agreement in Rome which is my favourite city for many, many reasons. Rome has been a
melting pot for people and cultures for 2500 years and as DENSsolutions wants to truly become a global company, having the people of QD Italy on board brings some very good “global” genes into our company. At DENSsolutions we will work hard to make this partnership with QD Italy a big success.”
Ben Bormans, CEO -DENSsolutions
 

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Uppsala University in Sweden expands its TEM capabilities using DENSsolutions In Situ systems

Uppsala University in Sweden expands its TEM capabilities using DENSsolutions In Situ systems

A DENSsolutions Wildfire double tilt (DT) system with a biasing expansion has been installed at the Uppsala University, Sweden.

Sharath Kumar Manjeshwar Sathyanath and Lars Riekehr checking the new Wildfire holder.

“It will be mainly used by the solid state chemistry group in order to investigate temperature behavior of alloys ”

 

Lars Riekehr – senior research engineer from the Ångström Laboratory in the Department of Engineering Sciences at Uppsala University.

Applications

The Wildfire DT system will be used by the group to research the phase transitions in metals and solar cells.

“After the installation the system was directly tested using solar cell samples. The researchers wanted to see how chemical inhomogeneities in the absorber layer would behave upon heating.”

In particular, Riekehr is pleased with certain features of the Wildfire system, such as the extra lateral shift on heating, the bulging and the stability. Additionally, the Biasing expansion will allow for precise operating voltage control.

He added that he was looking forward to the prospect of being able to offer in situ experiment results to anyone in the department who might need them.

Thank you for reading

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Queen’s University Belfast joins the group of Climate In Situ users

Queen’s University Belfast joins the group of Climate In Situ users

Dr. Miryam Arredondo-Arechavala (centre) in front of the (packed) Climate system, together with her PhD student Tamsin O’Reilly (left) and her Postdoc Dr. Kristina Holsgrove (right).

At the beginning of October, DENSsolutions installed a Climate G system at the Queen’s University Belfast, Northern Ireland, UK. 

“We are very excited to have the Climate system in-house. It all began about 3 years ago when I started describing these new amazing holders to my colleagues in the Chemistry department. It took some time but couldn’t be happier! We are really looking forward to trying the different experiments that we have been designing for so long… Now it’s time to get to work and hopefully won’t break too many chips on the way!”
Dr. Miryam Arredondo-Arechavala

Applications

The system will be mainly used by Dr. Miryam Arredondo-Arechavala and her group to study ferroelectrics and other functional materials. Alongside this, it will help accelerate research on ionic liquids performed by the QUILL Research Centre (Queen’s University Belfast’s Ionic Liquid Laboratories) and other catalyst projects at Queen’s University Belfast.

The DENSsolutions Climate holder inserted in the Talos TEM for the first time.

The group running the first test experiment using the Climate software.

Installation and first experiment

The system was installed in less than two days by our Climate product manager Ronald Marx. After this, Marx provided hands-on training for the new group of users. The team was able to start their first In Situ Gas & Heating experiment using their own sample of Zeolite particles which was dropcasted on to the Climate Nano-Reactor. Seeing the first results created a lot of enthusiasm among the group of principal investigators and their colleagues from the chemistry department.

Learn more about our Climate system:

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Our partnership with the EPSRC/Jeol Centre for Liquid Phase Electron Microscopy at UCL, London

Our partnership with the EPSRC/Jeol Centre for Liquid Phase Electron Microscopy at UCL, London

DENSsolutions LPEM systems enable advances in Life Science

Dr. Lorena Ruiz-Perez (left) and Prof. Guiseppe Battaglia (right)

On the 12th of November, DENSsolutions in cooperation with UCL and Quantum Design UK will be holding a Stream workshop at the EPRSC/Jeol Centre for Liquid Phase Electron Microscopy (LPEM) facility at UCL, London. At the LPEM facility, opened in 2017, Dr. Lorena Ruiz-Perez uses the DENSsolutions Liquid In Situ solutions to characterise soft organic nanomaterials via TEM imaging. In this article, we take a look at the LPEM research that Ruiz-Perez is doing within the Molecular Bionics lab.

Molecular Bionics

The goal of the group is to mimic specific biological functions and/or introduce operations that do not exist in nature by engineering bionic units made of polymers. This goal is achieved by a multidisciplinary team of chemists, physicists, mathematicians, engineers and biologists.

The LTEM team at the Molecular Bionics group is formed by Prof. Guiseppe Battaglia, director of the facility, Dr. Lorena Ruiz-Perez, manager of the facility. Cesare de Pace and Gabriele Marchello are PhD students involved in the experimental development of LTEM and LTEM image analysis respectively.

Inside the group, Dr. Lorena Ruiz-Perez has been using the DENSsolutions Ocean system to work mainly on two different projects.

Polymer assemblies

For the first project, she has been using the system to investigate soft matter polymer assemblies. As we have shown in one of our earlier articles, these assemblies have the potential to be used for targeted drug delivery inside the human body. These kinds of assemblies have been well studied using Cryogenic electron microscopy (cryo-EM). One of the main advantages of employing LPEM is that it allows us to gain new insights into the dynamic behaviour of these assemblies within a liquid that were not possible using images of the vitrified, i.e. frozen sample. In liquid, you can observe for instance the fluctuation of the polymer assembly membranes and hence investigate significant mechanical properties of the soft materials.

Proteins dynamic behaviour

Their second project involves investigating the dynamic behaviour of proteins in liquid. These proteins move by the so-called ‘Brownian motion’. The group wants to understand the structure of the proteins inside their native environment. While the protein is moving in water, they can capture many different profiles in order to reconstruct a 3D image of the protein structure. There is a minimum frame amount needed for the reconstruction, so the time component becomes fundamental in these in-situ studies. The investigation aims to create a library of proteins, like the RCSB PDB, with information on dynamic processes which can complement the information already supplied by the well established cryo-EM technique. Their first results, studying ferritin proteins, were presented at Manchester 2019*.

Schematic representation showing the temporal evolution of the density map reconstruction process of ferritin. A five second long video was segmented into five one second long sub-videos The brownian particle analysis algorithm extracted about 1000 particle profiles from each sub-video, generating five different density maps. The quality and resolution of the refined density maps resulted in being inversely proportional to the sample exposure time to the electron beam.

Proteins play a pivotal role in our physiological conditions and associated diseases. A deeper understanding of the kinetics governing the mechanistic behaviour of proteins in liquid media can lead to big improvements in drug design and ultimately in general healthcare.

*This manuscript is currently being updated with long molecular dynamics simulations of ferritin in solution.

The new Stream system

Now the group is advancing to the DENSsolutions Stream system, allowing them to do new kinds of experiments. The big advantage of the Stream system is that it can control the bulging of the viewing windows and therefore the liquid thickness. Controlling the bulging is essential for creating reproducible results. In previous LPEM in situ systems, the window bulging could differ between experiments, thus preventing experiment reproducibility.

Now with the Stream system, the bulging can be adjusted precisely for each new experiment, guaranteeing the same level of bulging and, therefore, consistent results. Controlling the liquid thickness is also important to achieve high contrast in organic and biological materials. The liquid thickness can be reduced up to the equilibrium where you have the highest possible resolution combined with a thick enough layer to have a realistic sample environment. 

Learn more about our Stream system:

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Milexia France SAS and DENSsolutions announce new partnership

Milexia France SAS and DENSsolutions announce new partnership

Distribution in France, Luxembourg and Wallonia (Belgium).

DENSsolutions is proud to partner with Milexia France SAS to serve the French, Luxembourg and Wallonian market in Europe. The Milexia France SAS Scientific Instrumentation Division has been a vendor of high-tech scientific instruments since 1981. They offer expert advice, comprehensive solutions, installation and technical testing on-site. DENSsolutions will strengthen their TEM portfolio and together we can build new relationships with French-speaking research groups.

“The DENSsolutions portfolio includes high end and innovative systems for in-situ transmission electron microscopy. These products will perfectly match with the high quality solutions we are used to promote, sell and service on the electron microscopy market for more than 30 years. With DENSsolutions, we are looking to remain active and even to futher develop our presence at the forefront of the new developments in transmission electron microscopy.”

Thierry Grenut, Business Unit Director – Milexia France SAS

“At DENSsolutions we are very excited to have Milexia as our distributor in France and Luxembourg as well as the French-speaking part of Belgium. Milexia is a very respected company in research markets where Electron Microscopy plays an important role. The in situ products and services from DENSsolutions help researchers and engineers develop new technologies that can be used to fight climate change, accelerate energy transition and develop clean and green industrial processes. France is leading many initiatives in all these fields as can be seen in the Paris Agreement on Climate Change. Milexia and DENSsolutions make a fantastic team for helping scientists and engineers advance their research.”

Ben Bormans, CEO -DENSsolutions

 

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Nanoscience Instruments and DENSsolutions announce new partnership

Nanoscience Instruments and DENSsolutions announce new partnership

DENSsolutions is proud to partner with Nanoscience Instruments to serve the US and Canadian markets. Nanoscience Instruments combines expertise in microscopy and surface science instrumentation with real-world solutions. This partnership will provide a synergistic fit to the core competencies of Nanoscience Instruments and the markets they serve.

Sebastian Kossek, co-owner of Nanoscience Instruments

“The DENSsolutions In Situ TEM solutions allow researchers to fully investigate real-world phenomena and achieve breakthrough science. The expansion to our range of products will further expand our reach into key strategic markets,” says Sebastian Kossek, co-owner of Nanoscience Instruments.

“As a company that specializes in surface science characterization and measurement instrumentation solutions, we are excited to have additional tools that are synergistic to our current and future customer base.”

“As scientists and researchers are looking to solve macro modern-day global challenges which society is facing, they need to understand materials down to the atomic level. The innovative and powerful In Situ TEM solutions DENSsolutions provides helps these researchers change the world, one atom at a time,” says Ben Bormans, CEO DENSsolutions.

“By incorporating all stages of the development model, In Situ TEM unlocks unprecedented research capabilities and moves nanoscience to the next level.”

Ben Bormans, CEO of DENSsolutions

Ben Bormans, CEO of DENSsolutions

“As scientists and researchers are looking to solve macro modern-day global challenges which society is facing, they need to understand materials down to the atomic level. The innovative and powerful In Situ TEM solutions DENSsolutions provides helps these researchers change the world, one atom at a time,” says Ben Bormans, CEO DENSsolutions.

“By incorporating all stages of the development model, In Situ TEM unlocks unprecedented research capabilities and moves nanoscience to the next level.”

Mark Flowers, co-owner of Nanoscience Instruments.

“The partnership with DENSsolutions opens new avenues for the current customer base and find additional overlaps with the other technologies we currently provide,” says Mark Flowers, co-owner of Nanoscience Instruments.

“Observing processes ‘on-site’ as they are occurring and under changing external stimuli is the paramount goal of In Situ, time resolved techniques.”

For more information about Nanoscience Instruments and the products and services they provide, visit us online at www.nanoscience.com