The first direct observation of pharmaceutical non-classical crystallization

Using the DENSsolutions Ocean LPEM system, Dr. Jennifer Cookman from the Bernal Institute in the University of Limerick and her colleagues were able to capture the intermediate pre-crystalline stages of a small organic molecule. This research marks the first ever direct observation of a pharmaceutical material undergoing non-classical crystallization, highlighting the rising value of in-situ TEM techniques in the pharmaceutical industry. 

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First Visualisation of Crystal Growth from Organic Molecules

Scientists characterise how flufenamic acid, a COX inhibitor, which is used in multiple industries, forms crystals from a liquid solution. The earliest stages of crystal growth are key to determining the final structure of a crystal, and scientists have visualised this process for the first time. Organic molecules were formed and grown in a liquid environment and characterised using the DENSsolutions Ocean In Situ system for Liquid Phase Electron Microscopy (LPEM).

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