DENSsolutions partners with Bioz for AI-powered scientific search

DENSsolutions partners with Bioz for AI-powered scientific search

We are thrilled to announce a significant enhancement to our website: the integration of the Bioz search engine – a cutting-edge tool empowering you to discover relevant publications with ease.

We recently integrated a state-of-the-art publications search tool, powered by cutting-edge artificial intelligence technology, across multiple pages on our website. Developed by Bioz, this innovative tool seamlessly scans through vast repositories of scientific papers, providing you with access to a wealth of information through sophisticated filtering capabilities.

Explore our new-and-improved Publications page

Previously, our Publications page allowed visitors to filter papers based solely on the type of DENSsolutions product used – namely Wildfire, Lightning, Climate or Stream. However, we understand that researchers appreciate more advanced search and filtering options to find tailored publications relevant to them. Therefore, we aimed to implement a tool on our website that would enable visitors to search for direct keywords applicable to their application or research focus. Moreover, a tool that would allow visitors to filter by the technique used, journal and even authors involved. This is precisely where Bioz comes in. You can now explore the tool on our updated Publications page. We would also like to highlight that with Bioz, you can make use of two unique features – the Charts and Maps feature. With Charts, you can visualize the popularity of all relevant techniques to in situ TEM, such as 4D-STEM, EELS and EDX. Moreover, the Maps feature allows you to see where all the authors of the papers are based.

Explore our updated product pages

Aside from the updates made to our Publications page, we’ve also revamped our product pages to allow for seamless searching of relevant publications as you acquaint yourself with each product. You can easily access these product pages through the links provided below. Note that as our latest solution Lightning Arctic was just launched some months ago, we plan to incorporate the Bioz platform directly into its dedicated webpage as publications begin to accumulate. 

About Bioz

Bioz, an AI software company based in Silicon Valley, uses AI, machine learning and natural language processing in order to extract experimentation data from scientific articles. Bioz AI was developed by AI experts from Microsoft and Google, and with Nobel Prize winners in chemistry. The Bioz search engine offers researchers billions of data-driven product, technique and protocol recommendations. By harnessing the power of AI, Bioz provides researchers with an unprecedented amount of summarized scientific experimentation knowledge right at their fingertips. They are used by over 2 million researchers from over 17,000 different universities and companies in 196 countries. Their search engine is fueled with 300,000 million different products, 50,000 suppliers and 3,000 research techniques. 

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Meet our new Senior Operations Manager – Carl Hansen

Meet our new Senior Operations Manager – Carl Hansen

We are excited to announce the expansion of our team with a new wonderful colleague: Carl Hansen.

DENSsolutions Eva Bladt

We recently welcomed Carl Hansen to the DENSsolutions family, whose addition underscores our unwavering commitment to innovation and excellence. Stepping into the role of Senior Operations Manager, Carl brings a wealth of experience and expertise to oversee and optimize various operational facets at DENSsolutions. With a comprehensive background in supply chain management, Carl’s responsibilities encompass leading our Operations team, refining logistics processes and ensuring operational efficiency to support our strategic objectives. By leveraging new technologies and fostering strong collaborations with key stakeholders, Carl’s overarching goal is to establish a world-class operational framework aimed at maximizing efficiency and transforming our supply chain into a strategic asset, driving DENSsolutions’ growth and competitiveness in the market. In this article, we invite you to learn more about Carl’s background, education, experience and pivotal role at DENSsolutions.

Get to know Carl: Personally

“My name is Carl Hansen, and I was born in 1986 in Minnesota, the United States,  but I grew up in Marietta, Georgia just outside of Atlanta. In 2010, I moved to Quito, Ecuador to finalize my MBA and later moved to Bogota, Colombia on 2012 where I met my lovely wife Lina. Together we moved to the Netherlands in 2014. In August 2023 I was naturalized as a Dutch citizen, making me a dual national of the United States and the Netherlands. I speak fluent Spanish and am on a continuous journey to improve my Dutch. I have a 3 ½ year old French Bulldog named Bruna Fiona de l’Avesnois (aka “Goomba”) who I’m absolutely obsessed with. My hobbies are cooking, baking & hosting, collecting and caring for houseplants and playing poker and board games. I love to travel and always look for an excuse to visit new places and eat local cuisine. I believe in giving back to the community and strive to always be either donating to or volunteering for something. A few weeks ago I made my 10th blood donation in the Netherlands at Sanquin, which I’m very proud of.”

“I decided that I wanted my next job to be back in operations, but this time at a smaller company with a strong sense of community, a big growth potential in future-looking technologies, and a product that is not environmentally harmful: Hello DENSsolutions!” – Carl Hansen

Get to know Carl: Professionally

“I did my undergrad at Georgia State University in Spanish Language & Culture minoring in Business Administration. This program was a prerequisite for the International MBA Program where some courses and the professional internship must be done in a Spanish-speaking country. I also hold several professional certifications: CSCP & CPIM from the Association for Supply Chain Management; Lean Six Sigma Green Belt from SABIC; Teacher of English to Speakers of Other Languages (TESOL) from the University of Georgia, EHBO First Responder from the Dutch Red Cross, among others.

I started working at 14 at McDonald’s where I learned the importance of Spanish in communicating with customers and colleagues. I also was introduced to McDonald’s world-class operational procedures and quality control mechanisms. From the age of 14 to 21 I was continuously employed part-time at restaurants while I studied. Those experiences ultimately inspired me to choose the aforementioned university path. In my late teens and early twenties I backpacked extensively through Latin America which opened my eyes to the lack of resources and education many communities struggle with. That led me to an interest in non-profit work in microfinance and community business development, and ultimately to my MBA internship in Quito, Ecuador at CARE, where I worked on micro-tourism development and AIDS awareness programs in rural indigenous communities. 

After CARE I wanted to stay in South America but couldn’t find full time work in non-profit so I moved to Bogota, Colombia to teach at EAN University, in hopes that academia could also be a meaningful way to serve the community. The university environment very fortunately brought me in contact with many high-profile Colombian business leaders and politicians which ‘re-inspired’ me to get back into corporate life, moving away from non-profit and academia. One of these contacts was a recruiter for SABIC based in the Netherlands who offered me a supply chain position in Bergen op Zoom. So together with Lina we packed our bags and set out on the Dutch adventure. I worked at SABIC for just over 2 years as a Demand Planner where I earned my APICS and Six Sigma credentials. I left SABIC to join HYVA as its Global Sales & Operations Planning Manager where I worked for 3.5 years improving supply chain operations and cross-functional collaboration. I sidestepped from that role into a junior financial controller position to strengthen my financial acumen. After 3.5 years in finance (and 7 years at Hyva) I felt I had learned what I needed about finance and contributed as much as I could to the supply chain function. I decided that I wanted my next job to be back in operations, but this time at a smaller company with a strong sense of community, a big growth potential in future-looking technologies, and a product that is not environmentally harmful: Hello DENSsolutions! I feel thankful and blessed to be here and look forward to growing together with this great group of people and products.”

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Breaking boundaries: Electrochemical impedance spectroscopy meets environmental TEM

Breaking boundaries: Electrochemical impedance spectroscopy meets environmental TEM

Employing the DENSsolutions Lightning system, researchers were able to apply a novel integrated EIS-ETEM approach to a common ceramic electrolyte, subjecting it to an array of stimuli, such as reactive gases, elevated temperatures and applied electrical potentials.

Original article by Ma et al.

Preparing and conducting high-temperature solid-state electrochemical TEM – particularly relevant to solid oxide fuel and electrolysis cells (SOFC and SOEC) – poses a number of challenges. These challenges include ensuring mechanical stability during chip mounting, preventing sample fracture or loss of electrical contact and minimizing unavoidable leak currents through the chip components. Despite its many challenges, the integration of electrical impedance spectroscopy and environmental TEM uniquely facilitates the direct correlation between electrochemical activity and the nanoscale structure and composition of materials. In a recent paper published in Small Methods – involving our dear user at the Technical University of Denmark (DTU), Dr. Søren Bredmose Simonsen – the DENSsolutions Lightning system was utilized to study micro gadolinia-doped ceria (CGO). The behavior of CGO, a ceramic electrolyte with various electrochemical properties, was investigated under a diverse range of stimuli, including reactive gasses (O₂ and H₂/H₂O), elevated temperatures (room temperature — 800 °C) and applied electrical potentials. Importantly, this research marks a significant advancement in materials science, pioneering the integration of EIS with in situ ETEM. 

CGO sample structure

Dr. Simonsen and his fellow collaborators meticulously designed the CGO sample for operando EIS-TEM investigations. A snapshot of the mounting process on the DENSsolutions Lightning Nano-Chip is shown in Figure 1b below. With a thin central part flanked by thick side parts, this sample configuration facilitates the separation of the contribution of bulk charge transport and the surface reaction processes. Notably, Dr. Simonsen emphasized the unique benefits of the Lightning Nano-Chip, highlighting its advantageous geometry. He explained, “The geometry of the DENSsolutions Lightning Nano-Chip is uniquely beneficial for our studies as it features a relatively long distance between the heater and the sample region. This allows us to mount and post-thin samples without the risk of creating pathways for leak current between the heater and sample or biasing electrodes.”

Figure 1: CGO sample mounted on a DENSsolutions Lightning Nano-Chip, visualized by SEM, TEM and HRTEM imaging.

EIS electrical circuit model

The researchers then explored the EIS spectra under three different gas environments at temperatures from 500 °C to 800 °C (see Figure 2 below). The Nyquist plots from EIS data reveal two distinct arcs, each representing different electrochemical processes. Through electrical circuit modeling, the contributions of resistances and capacitances are shown. Notably, the surface exchange reaction resistance exhibits a clear temperature dependence, reflecting thermally activated processes for both the transport and surface reaction.

Figure 2: EIS spectra (symbols) and fittings (lines) recorded in a) 3 mbar O₂ and in a H₂/H₂O with partial pressure ratio of b) 0.003 and c) 0.8; 10 kHz (square); 100 Hz (diamond), 1 Hz (circle), 0.1 Hz (triangle) are noted on the spectra, with hollow symbols.

Schematic illustration of CGO sample

In Figure 3 below, a schematic diagram of the differences for the CGO TEM sample in O₂ and H₂/H₂O is presented. Notably, in both O₂ and H₂/H₂O atmospheres, the conductivity and surface exchange reaction of CGO demonstrate notable dependencies on the gas environment. In the two scenarios, there are distinct chemical reaction formulas. In O₂, CGO predominantly conducts ions, confining the active surface near the Pt current collector. However, in the H₂/H₂O environment, electrons flow through CGO’s side parts, activating the entire surface.

Figure 3: Illustration of active surface area for Pt-CGO as a) pure ionic conductor and as b) mixed electronic/ionic conductor. Arrows indicate the direction of ions (red) and electrons (navy).

Electrochemical EIS meets TEM

The researchers then analyzed the transport and surface exchange resistance from the EIS measurements in each type of gas environment separately. Figure 4 below delves into the temperature and oxygen partial pressure (pO₂) dependence of CGO conductivity and surface exchange resistivity in different gas atmospheres. Notably, the conductivity in O₂ exhibits a characteristic temperature-dependent behavior, aligning closely with reference data for bulk polycrystalline CGO. Conversely, in H₂/H₂O environments, the conductivity shows a marked increase with decreasing oxygen partial pressure, indicative of a shift towards mixed electronic and ionic conduction. Moreover, the surface exchange resistance demonstrates a consistent decrease with increasing H₂/H₂O ratio, underscoring the influence of electronic charge carriers on electrochemical processes. 

Figure 4: Electrochemical EIS-TEM measurements of CGO in different atmospheres via Arrhenius plots.

A novel integration

Dr. Simonsen and his fellow collaborators performed a comprehensive in situ TEM heating and biasing study using the DENSsolutions Lightning system, elucidating the nuanced interplay between gas environment, temperature and material properties of micro gadolinia-doped ceria, a common ceramic electrolyte. This innovative research taps into new academic frontiers by combining electrochemical impedance spectroscopy with in situ environmental transmission electron microscopy investigations. Importantly, the developed EIS-TEM platform in this study is an important tool in promoting the understanding of nanoscale processes for green energy technologies, such as solid oxide electrolysis/fuel cells, batteries, thermoelectric devices and many more. 

“The geometry of the DENSsolutions Lightning Nano-Chip is uniquely beneficial for our studies as it features a relatively long distance between the heater and the sample region. This allows us to mount and post-thin samples without the risk of creating pathways for leak current between the heater and sample or biasing electrodes. Moreover, if not for the Lightning system’s low internal capacitance and high resistance, it would not have been possible to conduct electrochemical measurements for our materials.”

Dr. Søren Bredmose Simonsen   Senior Research  |  Technical University Denmark

Original article:

 

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Thomas article feature image

Lightning system helps uncover the interaction mechanism in reactive metal-ceramic system, Al-SiC

The DENSsolutions Lightning system was utilized to reveal the evolution mechanism of the Al–AOL–SiC system under heating and biasing conditions and under an ultrahigh resolution of 4 Å.

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Radboudumc expands its bio-research capabilities with newly installed DENSsolutions Stream system

Radboudumc expands its bio-research capabilities with newly installed DENSsolutions Stream system

We are excited to announce that DENSsolutions has installed a Stream system at the renowned Radboud University Medical Center (Radboudumc) in Nijmegen, the Netherlands. In this article, we interview Luco Rutten, PhD Candidate at Radboudumc, to learn more about the institute’s electron microscopy center, the team’s research direction and the pivotal role our Stream system will play in advancing their bio-research initiatives.

What is the Radboudumc Electron Microscopy Center known for?

“The Radboudumc Electron Microscopy (EM) Center, established in 2019 under the leadership of Dr. Anat Akiva and Prof. Dr. Nico Sommerdijk, operates as part of the RTC Microscopy within Radboud University Medical Center in Nijmegen, The Netherlands. Specializing in cutting-edge imaging and analysis techniques, including cryo-correlative light electron microscopy (cryo-CLEM), the EM Center serves users from both academia and industry. Notably, the center is equipped with a recently installed 200 kV Thermo Fisher Scientific TALOS F200C-G2 transmission electron microscope, featuring a Falcon 4i Direct Electron Detector, segmented STEM detector and EDS detector.”

What type of applications are the EM Center’s users interested in using Stream for?

“Since the Electron Microscopy Center is part of the University Medical Center, we are especially interested in using Stream to study biological and biomimetic processes under relevant conditions. For instance, the aggregation of protein-calcium complex and the biomineralization of organic scaffolds such as collagen mimicking health and disease. By adding the dynamic information from liquid phase EM to our cryo-CLEM workflow, we can unravel the mechanisms at the nanoscale of life.”

What particular features of Stream stood out to you?

“With our aim to study biological processes, the ability of the Stream system to seamlessly approach physiological conditions is of great importance. Since life occurs at 37 °C, precise control over the temperature is critical. Moreover, with Stream we are able to control liquid flow, enabling us to work with concentrations very close to physiological conditions. Additionally, we often deal with hybrid systems composed of both organic and inorganic materials, which can limit the contrast. By controlling the bulging of the windows through adjusting the front and back pressure, we’re able to reduce the liquid thickness as much as possible.

Could you tell us a bit more about the funding granted to acquire the systems?

“Prof. Dr. Nico Sommerdijk, the lead PI of the project titled ‘In Situ Imaging of Biological Materials with Nanoscale Resolution using Liquid Phase Electron Microscopy’, was awarded the NWO-groot grant of 1.5 million euros by the Dutch Scientific Organization to acquire state-of-the-art equipment for liquid phase electron microscopy to study biological processes. Part of this grant was used to acquire the Stream system. The aim of the program is to establish a globally unique facility dedicated to liquid phase electron microscopy on biological materials. The integration of the latest developments in software, hardware and sample preparation techniques will broaden the range of biological materials that can be investigated.”

In your experience so far, how have you found working with Stream?

“Operating the Stream system becomes quite routine after working with it a couple of times. The recent workshop organized by DENSsolutions for Stream users (see image below) provided a valuable opportunity to learn from experts like Dr. Hongyu Sun, DENSsolutions Senior App Scientist, and exchange experiences in working with the holder with other participants.

From left to right: Dr. Hongyu Sun (DENSsolutions), Luco Rutten (Radboudumc), Yannick Rutsch (FZ Jülich) and Rebecka Rilemark (Chalmers University of Technology)

Luco Rutten
PhD Candidate |  Electron Microscopy Center, Radboudumc

Luco Rutten received his Master’s degree in Chemistry and Chemical Engineering from the Eindhoven University of Technology. He is in his last year of his PhD at \Radboudumc under the supervision of Dr. Elena Macías-Sánchez and Prof. Dr. Nico Sommerdijk. As part of the Biomineralized Tissues group and the Electron Microscopy Center, he is using advanced electron microscopy to study bone mineralization mechanisms.

Discover the team’s publications:

 

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Meet our new colleagues Dr. Andrés Alvarez and Zhichao Liu

Meet our new colleagues Dr. Andrés Alvarez and Zhichao Liu

We are excited to announce the expansion of our team with two new wonderful colleagues: Andrés, our System Architect (Precision Engineer), and Zhichao, our Field Service Engineer.

DENSsolutions Eva Bladt

We are thrilled to introduce two of our newest colleagues who, just like the rest of our team, exemplify our commitment to innovation and excellence: Dr. Andrés Alvarez and Zhichao Liu. Dr. Andrés Alvarez takes the helm as our System Architect (Precision Engineer), who will play a key role in designing the architecture that underpins our cutting-edge solutions, from design all the way to implementation. With an extensive background in mechanical engineering, Andrés brings a unique blend of technical expertise and a creative touch to his projects. His role is instrumental in ensuring and boosting the reliability, robustness and ease-of-use of our solutions by incorporating top-notch precision engineering practices.

We are also thrilled to welcome Zhichao Liu, our new Field Service Engineer, who will play a crucial role in the installation, service and repair of our in situ electron microscopy solutions, both globally and remotely. With a background in electrochemistry and micro- and nano-engineering/science, and experience in providing high-level training for microscopy techniques such as atomic force microscopy (AFM) and Raman microscopy, Zhichao is well-equipped as our new Field Service Engineer to ensure that our valued customers have all the support they need. In this article, we invite you to get to know Andrés and Zhichao better, delving into their background, education and experience as well as their role at DENSsolutions.

Meet Dr. Andrés Alvarez

“My name is Andrés Alvarez, and I come from Bogotá, Colombia. I was born in 1981, the youngest of three siblings. From an early age, I was fascinated with household devices, often taking them apart and putting them right back together. This early curiosity, coupled with the unwavering support of my parents, sparked my lifelong passion for science and engineering. I studied Mechanical Engineering at Universidad Nacional de Colombia, broadening my technical perspective with courses in product design, automation and electrical engineering. As I neared the end of my undergraduate studies, I contemplated a career in academia and dreamed of pursuing further studies abroad. However, a unique opportunity arose when I started working for Alfagres, a notable manufacturer of ceramic tile products and paints. At Alfagres, I was focused on developing production equipment. But my academic dreams were not entirely sidelined as I received a scholarship to pursue my master’s degree in Mechanical Engineering through the Erasmus Mundus program. This led me to study at the renowned universities of Universitat Politècnica de Catalunya and Ecole Nationale de Sciences Appliquées de Lyon.

“Outside of my professional journey, I have many interests – I grew up liking the television, music and videogames of the eighties and nineties, with a lot of influence from my older brother. I’ve also always enjoyed fantasy and science fiction novels. Nowadays. I have a wide-ranging taste in music and enjoy playing video games, musical instruments and board games.” – Dr. Andrés Alvarez

My pursuit of knowledge then led me to a PhD in the Netherlands at Delft University of Technology, where I was part of the Intelligent Mechanical Systems group, focusing on the ‘automatic generation of control software for mechatronic systems.’ This project allowed me to collaborate with high-tech companies, expanding my knowledge of system architecting and model-based design. In 2011, I successfully defended my PhD thesis, titled ‘Architecture-centric design: Modeling and applications to control architecture generation.’ Stepping away from academia and transitioning to industry instead, I first worked at Sonion, developing miniature devices integrating electro-acoustical sensors and actuators for the hearing-aid industry. Then I joined the Dutch Ophthalmic Research Center as a Systems Architect, where I contributed to the development of the EVA platform for ophthalmic surgery systems. This product interfaces with a wide range of surgical instruments, providing approximately 10 different surgical functions. It also features a graphical user interface for real-time adjustments, ensuring a seamless match with the surgery plan and addressing any unexpected situations in the operating room. Now, at DENSsolutions, I’m excited to embrace new challenges in the complex and dynamic field of in situ microscopy. This role involves seeking innovative solutions to product architecture, and I believe that my diverse background in academia and industry has equipped me with a unique set of skills to tackle the cutting-edge challenges of this industry.”

Meet Zhichao Liu

“My name is Zhichao Liu, and I was born and raised in China. My scientific journey began at Ocean University of China, where I pursued a degree in polymer materials and engineering. My inspiration to undergo this degree came from understanding the endless potential of polymers in reshaping the future. My studies covered diverse subjects, ranging from the intricacies of mathematics and physics to the fascinating world of polymer materials and electrochemistry. After finishing my bachelor’s degree, I moved to the Netherlands to pursue a master’s degree in Electrochemistry and Nanoscience at Leiden University. It was specifically during this time that I uncovered my passion for electrochemistry and micro- and nano-engineering, setting the course for many of my future endeavors. This passion led me to pursue a PhD in electrochemical sensor fabrication with micro and nano techniques at Delft University of Technology (TU Delft). During my doctoral journey, I successfully fabricated electrochemical sensor chips using inkjet printing methods. These cutting-edge chips are adept at monitoring a wide array of molecular levels within the human body, such as dopamine, glucose and tyrosine. Beyond research, I actively participated in various roles. One notable role I undertook was a Lab Instructor at the PME department’s chemistry lab at TU Delft, where I was responsible for providing comprehensive training to all masters, doctoral and post-doctoral students before they used the chemistry lab. I also needed to understand their research objectives, assisting them in devising experimental schemes and alerting them to potential risks and hazards.

“Aside from my professional life, one of my greatest hobbies is swimming, especially in the sea. Beyond my love for swimming, I’ve always had an appreciation for nature, immersing myself in it through hiking expeditions when I can. I also enjoy keeping myself busy with projects where I’m able to exercise my love for invention, so I’m often crafting various gadgets and devices at home. In fact, my latest project to date is designing and developing an electric-foil surfboard.” – Zhichao Liu

Additionally, at TU Delft I served as the instructor for equipment like the electrochemical workstation, and techniques like AFM and Raman microscopy. Moreover, my duties in this capacity included not only training users but also daily maintenance of the instruments, troubleshooting and coordinating repairs with the manufacturers. Importantly, it was during my tenure as a Raman instructor that I became familiar with DENSsolutions. I was particularly impressed to learn of the company’s dedication to technological innovation, successfully developing cutting-edge in situ solutions that hold a significant position in the market. As a Field Service Engineer at DENSsolutions, my primary objective is to ensure optimal performance and longevity of our in situ electron microscopy solutions. I’m committed to providing efficient installations, timely services and prompt repairs to maintain and enhance customer trust and satisfaction. Additionally, I aim to continually learn and gather feedback to appropriately address evolving customer needs, furthering the company’s reputation for excellence.“

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